 Duphaston medicineCommon usesDuphaston is used for several different menstrual disorders that occur due to a lack of progesterone in the body. Dydrogesterone is necessary for the maintenance of a healthy endometrium, the lining of the uterus, required for pregnancy. The body produces Dydrogesterone at certain times of the month, making the uterus hospitable to a fertilized embryo. If no embryo appears, progesterone levels drop and the body sheds the lining of the uterus, resulting in a menstrual period. Taking Duphaston helps to regulate this process in women whose progesterone levels are low, so that they may be maintained at the level required for health and fertility. Duphaston is used as a treatment for several different conditions related to progesterone production. If a woman experiences abdominal pain or bleeding during a pregnancy, or if she is pregnant but has a history of miscarriages, Duphaston can help sustain the necessary levels of hormones required to maintain a healthy pregnancy. It also relieves severe menstrual cramps or regulates menstrual periods if you have difficulty in these matters due to a progesterone deficiency. It helps treat endometriosis, an inflammation of the lining of the uterus, and helps regulate irregular menstrual cycles. It can stabilize the level of progesterone, thereby treating premenstrual syndrome. It also can help prevent the excessive growth of the endometrium that is a result of estrogen hormone replacement therapy. It is also used to treat infertility in women by re-establishing the levels of progesterone required for women to become pregnant. Before using Irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Combined with an estrogenic substance, Duphaston can be applied in secondary amenorrhoea, dysfunctional uterine bleeding and post-menopausal complaints where endogenous progesterone deficiency is implicated. Directions In general The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy — HRT), Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. If on continuous estrogen therapy: Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. If on cyclic estrogen therapy: Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. Cautions Duphaston should not be given to patients with undiagnosed vaginal bleeding nor to those with a history of thromboembolic disorders. Duphaston should be used with caution in patients with cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine. It should be used with care in persons with a history of mental depression. Store in a dry, dark place at temperatures not exceeding 25°C. Keep out of reach of children. Possible side effects Side effects of Duphaston may include gastro-intestinal disturbances, allergic skin rashes or urticaria, changes in libido, acne, fluid retention, mass gain, mental depression and breast changes, which may include discomfort or gynaecomastia. Alterations in liver function tests have been reported and less frequently jaundice. In a small percentage of the treated cases, breakthrough bleeding may occur, which can be prevented by increasing the dosage. During the clinical application of Duphaston, no virilising side effects were observed. Overdose See " Possible side effects ". Treatment is symptomatic and supportive. Additional information Duphaston should be used with caution in patients with cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine. It should be used with care in persons with a history of mental depression. Drug interactions There are no reported significant interactions with this medicine. Womens Health Medications
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